demonstrations have made mechanical resonators attractive candidates for quantum information processing, metrology, and tests of quantum gravity theories. Here, we experimentally demonstrate a direct quantum-acoustic equivalent of a single-atom laser. A single superconducting qubit coupled to a high-overtone bulk acoustic resonator is used to drive the onset of phonon lasing. We observe the absence of a sharp lower lasing threshold and characteristic upper lasing threshold, unique predictions of single-atom lasing. Lasing of an object with an unprecedented 25 ug mass represents a new regime of laser physics and provides a foundation for integrating phonon lasers with on-chip devices.