ZZ crosstalk have mainly relied on specific chip design that can complicate chip fabrication and aggravate decoherence. To some extent, special chip design can be avoided by relying on pulse optimization to suppress ZZ crosstalk. However, existing approaches are non-scalable, as their required time and memory grow exponentially with the number of qubits involved. To address the above problems, we propose a scalable approach by co-optimizing pulses and scheduling. We optimize pulses to offer an ability to suppress ZZ crosstalk surrounding a gate, and then design scheduling strategies to exploit this ability and achieve suppression across the whole circuit. A main advantage of such co-optimization is that it does not require special hardware support. Besides, we implement our approach as a general framework that is compatible with different pulse optimization methods. We have conducted extensive evaluations by simulation and on a real quantum computer. Simulation results show that our proposal can improve the fidelity of quantum computing on 4∼12 qubits by up to 81× (11× on average). Ramsey experiments on a real quantum computer also demonstrate that our method can eliminate the effect of ZZ crosstalk to a great extent.