A significant challenge impeding scaling is crosstalk, characterized by unwanted interactions among neighboring components on quantum chips, including qubits, resonators, and substrate. We motivate a general approach to systematically resolving multifaceted crosstalks in a limited substrate area. We propose Qplacer, a frequency-aware electrostatic-based placement framework tailored for superconducting quantum computers, to alleviate crosstalk by isolating these components in spatial and frequency domains alongside compact substrate design. Qplacer commences with a frequency assigner that ensures frequency domain isolation for qubits and resonators. It then incorporates a padding strategy and resonator partitioning for layout flexibility. Central to our approach is the conceptualization of quantum components as charged particles, enabling strategic spatial isolation through a ‚frequency repulsive force‘ concept. Our results demonstrate that Qplacer carefully crafts the physical component layout in mitigating various crosstalk impacts while maintaining a compact substrate size. On device topology benchmarks, Qplacer can reduce the required area for theoretical crosstalk-free layout by 2.61x and 2.25x on average, compared to the results of manual design and classical placement engines, respectively.