enabling practical control while minimizing decoherence and suppressing significant crosstalk. In this paper, we propose a neural network-based frequency configuration approach. A trained neural network model estimates frequency configuration errors, and an intermediate optimization strategy identifies optimal configurations within localized regions of the chip. The effectiveness of our method is validated through randomized benchmarking and cross-entropy benchmarking. Furthermore, we design a crosstalk-aware hardware-efficient ansatz for variational quantum eigensolvers, achieving improved energy computations.