qubits, traditionally controlled through individual circuitry, currently face a formidable scalability challenge due to the excessive use of wires. This challenge is nearing a critical point where it might soon surpass the capacities of on-chip routing, I/O packaging, testing platforms, and economically feasible solutions. Here we introduce a multiplexed control scheme that efficiently utilizes shared control lines for operating multiple qubits and couplers. By integrating quantum hardware-software co-design, our approach utilizes advanced techniques like frequency multiplexing and individual tuning. This enables simultaneous and independent execution of single- and two-qubit gates with significantly simplified wiring. This scheme has the potential to diminish the number of control lines by one to two orders of magnitude in the near future, thereby substantially enhancing the scalability of superconducting quantum processors.