strategies, such as hardware isolation and dynamical decoupling, face limitations in scalability, experimental feasibility, and robustness against complex noise sources. In this manuscript, we propose a physics-guided neural control (PGNC) framework to generate robust control pulses for superconducting transmon qubit systems, specifically targeting crosstalk mitigation. By combining a hardware aware parameterization with a Hamiltonian-informed objective that accounts for condition-dependent crosstalk distortions, PGNC steers the search toward smooth and physically realizable pulses while efficiently exploring high dimensional control landscapes. Numerical simulations for the CZ gate demonstrate superior fidelity and pulse smoothness compared to a Krotov baseline under matched constraints. Taken together, the results show consistent and practically meaningful improvements in both nominal and perturbed conditions, with pronounced gains in worst-case fidelity, supporting PGNC as a viable route to robust control on near-term transmon devices.