is challenging in the presence of realistic couplings to an environment. Here, we introduce and assess protocols that can be used in cavity QED to perform high-fidelity quantum state transfer and fast quantum nondemolition qubit readout through Hamiltonian engineering. We show that high-fidelity state transfer between a cavity and a single qubit or between a cavity and the collective mode of a qubit ensemble can be performed, even in the limit of strong dephasing due to inhomogeneous broadening. Moreover, we show that large signal-to-noise and high single-shot fidelity can be achieved in a cavity-based qubit readout, even in the weak-coupling limit. These ideas may be important for novel systems coupling single spins to a microwave cavity.