As a matter of fact, errors in Quantum Processing Units (QPUs) incorporate various aspects of context-dependability which are overlooked by the majority of the commonly used QCVV protocols. As QCVV protocols are indispensable when it comes to characterizing and evaluating quantum operations, there is a serious need for a detailed characterization taking into account such aspects. In this work, we address these shortcomings by designing a context-aware version of the gate set tomography (GST) protocol. Our experiment selection approach is based on a polynomial quantification of the accumulation of errors within the designed circuits. Using simulated QPUs, we show that this technique enables a characterization with an inaccuracy reaching 10−5. Furthermore, we use our proposed protocol to experimentally infer context-dependent errors, namely crosstalk and memory effects, in a publicly accessible cloud-based superconducting qubits platform. Our results show that when the GST is upgraded to include such features of context-awareness, a large coherence in the errors is observed. These findings open up possibilities of drastically reducing the errors within the currently demonstrated QPUs.