This is essential for applications such as qubit readout, quantum sensing, and communication, where signal fidelity and coherence preservation are critical. Unlike CMOS and HEMT amplifiers used in conventional RF systems, JPAs are specifically optimized for millikelvin (mK) cryogenic environments. CMOS amplifiers offer good integration but perform poorly at ultra-low temperatures due to high noise. HEMT amplifiers provide better noise performance but are power-intensive and less suited for mK operation. JPAs, by contrast, combine low power consumption with ultra-low noise and excellent cryogenic compatibility, making them ideal for quantum systems. The first part of this study compares these RF amplifier types and explains why JPAs are preferred in cryogenic quantum applications. The second part focuses on the design and analysis of JPAs based on both single Josephson junctions and junction arrays. While single-junction JPAs utilize nonlinear inductance for amplification, they suffer from gain compression, limited dynamic range, and sensitivity to fabrication variations. To overcome these challenges, this work explores JPA designs using Josephson junction arrays. Arrays distribute the nonlinear response, enhancing power handling, linearity, impedance tunability, and coherence while reducing phase noise. Several advanced JPA architectures are proposed, simulated, and compared using quantum theory and CAD tools to assess performance trade-offs and improvements over conventional designs.