a generic cavity optomechanical setup to non-reciprocally amplify microwave signals above 3 GHz in one direction by 9 decibels, and simultaneously attenuate the transmission in the opposite direction by 21 decibels. We use a device including two on-chip superconducting resonators and two metallic drumhead mechanical oscillators. Application of four microwave pump tone frequencies allows for designing constructive or destructive interference for a signal tone depending on the propagation direction. The device can also be configured as an isolator with a lossless nonreciprocal transmission and 18 dB of isolation.