We present a control and measurement setup for superconducting qubits based on Xilinx 16-channel radio frequency system on chip (RFSoC) device. The proposed setup consists of four parts:multiple RFSoC FPGA boards, a setup to synchronise every DAC and ADC channel across multiple boards, a low-noise DC current supply for qubit biasing and cloud access for remotely performing experiments. We also design the setup to be free of physical mixers. The FPGA boards directly generate microwave pulses using sixteen DAC channels up to the third Nyquist zone which are directly sampled by its eight ADC channels between the fifth and the ninth zones.