electronics, this is a challenge because the Josephson junction devices they are based upon require tiny current pulses to create and manipulate the single flux quanta which guide their operation. Difficulty arises in transitioning these signals through large temperature gradients for connection to semiconductor components. In this work, we present nano superconducting quantum interference devices (SQUID) with critical dimensions as small as 10 nm from the high-transition-temperature superconductor YBa2Cu3O7−δ (YBCO). We integrate these nano-SQUIDs with nano-isolated inductively coupled control lines to create a low power superconducting output driver capable of transimpedance conversion over a very wide temperature range.