and develop concrete directions for achieving a giant amplification in photon transmission. We propose two architectures for scaling up the electronic gain medium: (i) N double quantum dot systems (N-DQD), (ii) M quantum dots arranged in series akin to a quantum cascade laser setup. In both setups, the fermionic reservoirs are voltage biased, and the quantum dots are coupled to a single-mode cavity. Optical amplification is explained based on a sum rule for the transmission function, and it is determined by an intricate competition between two different processes: charge density response in the gain medium, and cavity losses to input and output ports. The same design principle is also responsible for the corresponding giant amplification in other photonic observables, mean photon number and emission spectrum, thereby realizing a quantum device that behaves as a giant microwave amplifier.